With the advent of high throughput screening, currently more than half of all plastic products including bags, sheets, and pipes are manufactured my HME and therefore various polymers have been used to melt and form different shapes for a variety of industrial and domestic applications. Since then, it has been used in the plastic, rubber, and food manufacturing industry to produce items ranging from pipes to sheets and bags. Hot-melt extrusion technique was first invented for the manufacturing of lead pipes at the end of the eighteenth century. Process Technology of Hot-Melt Extrusion (HME) In this chapter, the hot-melt extrusion technique is reviewed based on a holistic perspective of its various components, processing technologies, and the materials and novel formulation design and developments in its varied applications in oral drug delivery systems. In addition to being a proven manufacturing process, HME meets the goal of the US Food and Drug Administration’s (FDA) process analytical technology (PAT) scheme for designing, analyzing, and controlling the manufacturing process via quality control measurements during active extrusion process. This makes HME an excellent alternative to other conventionally available techniques such as roll spinning and spray drying. Since the industrial application of the extrusion process back in the 1930’s, HME has received considerable attention from both the pharmaceutical industry and academia in a range of applications for pharmaceutical dosage forms, such as tablets, capsules, films, and implants for drug delivery via oral, transdermal, and transmucosal routes. HME has now provided opportunity for use of materials in order to mask the bitter taste of active substances. To date HME has emerged as a novel processing technology in developing molecular dispersions of active pharmaceutical ingredients (APIs) into various polymer or/and lipid matrices which has led this technique to demonstrate time controlled, modified, extended, and targeted drug delivery. This paper reviews the innumerable benefits of HME, based on a holistic perspective of the equipment, processing technologies to the materials, novel formulation design and developments, and its varied applications in oral drug delivery systems. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targeted drug delivery resulting in improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). If interested, please pm me.Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. I also have various other textbooks for Engineering drawing, AutoCAD 2010, AutoCAD vba, etc.
The Dynisco Injection Molders handbook: $20 The small booklet (15 pgs) is in decent condition as well and covers some general info about spinning, $30 for the pairĩ. Metal Spinning (Regan and Smith) & Metal Spinning (Boice Crane Booklet): The brown hardcover book is an original copy in very good condition. The Home Shop Machinists - Projects Seven: excellent condition, $15Ĩ. This is a really great old book old book on sand casting. Foundry Work: very good condition, some wear on corners of cover, but all pages are excellent. The complete handbook of Centrifugal Casting: excellent condition, soft cover $12Ħ. Lathe operation and Maintenance: near nwe condition, soft cover $20ĥ. Basic Machining Reference Handbook: new condition, hard cover $15Ĥ. Machine Tool Technology Basics: new condition, hardcover text book $20ģ. Audel Machine Shop Basics: new condition, $12Ģ. If your interested in something, just pm me with your address, and I'll determine the best shipping method and provide a cost.ġ. If you want to buy more than one book, I may ship using a different method, depending on weight. I would probably ship these USPS book rate, which is typically reasonable. Here's a list of books I'm clearing off of my book shelf.
0 kommentar(er)
